No more lying about your age: your DNA chemistry will let the world know exactly how old your cells are.
One scientist has put together an enormous amount of available bioinformatic information to conclude that the modifications of methylation in each cell’s DNA, which are part of the epigenetics of the cell, can be used as predictors of age.
Steve Horvath, from the University of California Los Angeles (UCLA) has published a paper in the open access journal Genome Biology with a new approach to the information already published by different laboratories in the past years. Importantly, he collected and analyzed large databases of DNA sequences, that were independently compiled in the past, but that could all be compared because they were obtained using the same DNA sequencing technology. The author acknowledges the “ generosity of hundreds of researchers” that provided the “unprecedented collection of DNA methylation data” in publicly available databases.
The silk road to epigenetics: the driving forces behind silkworm domestication
Silkworms are under the spotlight after the publication of a study where epigenetic modifications are compared between wild and domesticated varieties. This work unravels the mechanisms that led to the domestication of silkworms and the improvements in silk production about 5000 years ago in China.
The domesticated silkworm, Bombyx mori, was the focus of the study by Xiang and colleagues, published online on the 23rd of September 2013 in the journal BMC Genomics. Photo: Wikipedia
The domesticated silkworm has been artificially selected to produce more and better silk, the luxurious product that is so valued worldwide. It has been estimated that silk production has increased up to tenfold with sericulture (the breeding of silkworms for the harvesting of silk, also known as silk farming). For example, the domesticated variety shows nowadays a series of human-preferred traits such as faster growth, bigger cocoons and increased resistance to disease than the wild variety. Silk production is of great economical importance, especially in rural areas of the main producing countries, China and India, and research in these animals is expected to lead to an important increase in revenues. In addition, these are good model organisms for studies in invertebrates, as they easy to breed and have fast growth. Now, a team comprising scientists from various Institutes in China has asked the question: which are the main differences found in domesticated silkworms, apart from genetic divergences, that contribute to their particular characteristics?